They have wide ranging use in medical and commercial settings, with molecular weights (MW) that range from 200 to 35,000 grams/mol. The British Society for Allergy and Clinical Immunology (BSACI) has advised that individuals who have had a possible reaction to the first dose of a COVID-19 vaccine may be able to receive a second dose of vaccine, as per the management advice below: If symptoms began within 2 hours of the first vaccination, this could indicate an immediate-type allergic reaction: If symptoms began 2 or more hours after the first vaccination, this could indicate delayed urticaria/angioedema: Individuals with non-allergic reactions (vasovagal episodes, non-urticarial skin reaction or non-specific symptoms) to the first dose of a COVID-19 vaccine can receive the second dose of vaccine in any vaccination setting. 35 Sun W, et al. See the Figure below for a pictorial representation of this advice: “Flowchart for managing patients who have allergic reactions to the first dose of COVID-19 vaccine”, reproduced with kind permission from the authors of Public Health England’s Immunisation Against Infectious Disease (the Green book). Ann. However, AstraZeneca does not manufacture the raw materials used in its products, and the suppliers may periodically change. The oral rotavirus vaccine (Rotarix) contains about a gram of sugar (sucrose) to give it a pleasant taste. As well as allergy considerations associated with previous vaccination and to excipients, other considerations are as follows. If you need to know more and you're a healthcare professional in England, you can ask one of our experts for help. Though large … 18: Wang Y, Li C, Yi Y, Qin L, Zhao Y, Li G, Cong X, Cao S, Liang A. What factors need to be considered when prescribing for lactose intolerant adults? PubMed PMID: 23019864. Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the popular antiarrhythmic amiodarone. Some injected … 2021-02-13. This site uses cookies. 2005-11-20 . Discussion: Both etoposide and its excipient (polysorbate 80) are suspected of causing hypersensitivity reactions. Anaphylactoid Reactions Induced By Polysorbate 80 on Beagle Dogs. Those with a history of anaphylaxis to a vaccine, an injected antibody preparation or a medicine likely to contain PEG (e.g. Create . back About. acesulfame K, butylparaben, citric acid, flavoring, glycerin, high fructose corn syrup, polysorbate 80, propylene glycol, purified water, sodium benzoate, sorbitol solution, veegum and xanthan gum. Polysorbate 80 in Medical Products and Nonimmunologic Anaphylactoid Reactions. Is there a lactose-free hormone replacement therapy (HRT)? Compared to controls who had been exposed to polyethylene glycol 3350-containing bowel preparations without allergic reactions, both of the cases had significantly increased amounts of specific IgG and IgE antibodies which could bind specifically to polyethylene glycols. Previous allergy to foods is covered in Public Health England’s Immunisation Against Infectious Disease (the Green book) which states that individuals with previous allergy to food, including anaphylaxis, can receive the AstraZeneca COVID-19 vaccine. The authors found an average of 4 cases of anaphylaxis reported per year to the FDA from 2005-2017 where PEG 3350-containing bowel preparations or laxatives were the implicated culprit. those with allergies, including anaphylaxis, to a food, insect sting or most medicines (where the trigger has been identified), can proceed with vaccination as normal according to local guidelines, as long as they are not known to be allergic to any component (excipient) of the vaccine; anyone with a family history of allergies, a previous non-systemic reaction to a vaccine, hypersensitivity to non-steroidal anti-inflammatory drugs (e.g. Individuals with an allergy to polysorbate 80 should not receive the vaccine. Public Health England’s Immunisation Against Infectious Disease (the Green book) states that: Individuals with a history of immediate onset-anaphylaxis to multiple classes of drugs or an unexplained anaphylaxis should not be vaccinated with the Pfizer-BioNTech COVID-19 vaccine, except on the advice of an allergy specialist. Public Health England’s Immunisation Against Infectious Disease (the Green book) states that individuals with previous allergy to an identified drug, including anaphylaxis, can receive the AstraZeneca COVID-19 vaccine. Toothpastes contain excipients that can cause adverse reactions affecting the mouth and lips, and systemic hypersensitivity. Taste improvers. sorbate80. This emulsifier prevents sauces and salad dressings from separating. Main Menu. Individuals with an allergy to polysorbate 80 should not receive the vaccine. Many of the Tweens are considered to be carcinogens. BETR ALLERGY RELIEF- diphenhydramine hydrochloride tablet ... POLYSORBATE 80 (UNII: 6OZP39ZG8H) STEARIC ACID (UNII: 4ELV7Z65AP) TITANIUM DIOXIDE (UNII: 15FIX9V2JP) DIBASIC CALCIUM PHOSPHATE DIHYDRATE (UNII: O7TSZ97GEP) Product Characteristics: Color: PINK (dark) Score: no score: Shape: OVAL: Size: 10mm: Flavor: Imprint Code: L479;25 Contains Packaging # … Zhongguo Zhong Yao … PEG 3350 is currently contained in 1155 FDA approved medications and can more commonly be found in film coated tablets, topical gels, and parenteral steroids. The aim was to investigate the formation of … However, AstraZeneca does not manufacture the raw materials used in its products, and the suppliers may periodically change. Lack of contact with other ingredients during the manufacturing process cannot be guaranteed. Tell your doctor if you have ever had: radiation treatment; liver or kidney disease; breathing problems; or. The Journal of Allergy and Clinical Immunology: In Practice is an official journal of the AAAAI, focusing on practical information for the practicing clinician. PEG section modified, based on updated information from the Green Book. a hospital), and a 30 minute observation period is recommended. Allergy Asthma Immunol. Each of the cases had positive skin testing and reproducible symptoms to products containing either polyethylene glycol 3350, polysorbate 80, or both. They compared antibody concentrations to PEG 3350-exposed controls who had never reacted to it. Advice on managing anaphylaxis in the vaccination setting with specific reference to COVID-19 vaccines. These all appear to be immunologically cross reactive with polyethylene gylcols. Zhongguo Zhong Yao Za Zhi. The Stone and coworkers article noted below has the skin testing methodology well described. Allergy to a previous dose of AstraZeneca COVID-19 vaccine or other medicines may affect suitability for vaccination. common excipient and solubilizing agent used in the pharmaceutical industry 95(6) 2005: 593–539. Allergy to Poylsorbate 80 is extremely rare but would contraindicate receipt of the Astra Zeneca vaccine. Tween 80 is an ethoxylated hydrophilic non-ionic surfactant, which is used for the preparation of oil-in-water emulsions in pharmaceutical products, cosmetics, and industrial detergents. To better understand the mechanism of macrogol hypersensitivity in the two cases, they next sought to detect the presence of polyethylene glycol specific antibodies using modified ELISA techniques. Public Health England’s Immunisation Against Infectious Disease (the Green book) states that individuals with previous allergy to an identified drug, including anaphylaxis, can receive the AstraZeneca COVID-19 vaccine. The manufacturer states that the vaccine does not contain any soy. Public Health England’s Immunisation Against Infectious Disease (the Green Book) also states that it is unclear whether PEG is the only cause of allergic reactions in patients with systemic allergic symptoms after the first dose of the Pfizer-BioNTech vaccine. The BSACI advise in their COVID-19 Vaccinations and Allergies FAQ that polysorbate 80 is found in many vaccines including the influenza vaccine; they state that although polysorbate 80 is quite similar in structure to PEG, there are no reports of PEG-allergic patients reacting to it e.g. Polysorbate 80 is a common food additive used in several vaccines as an emulsifier (to hold other ingredients together). Macrogols, including polyethylene glycols (PEGs) and the structurally related polysorbates, are compounds whose primary feature includes polyether groups. If the reaction was self-limiting or resolved with oral antihistamine, the individual can have the second dose using the same vaccine in any vaccination setting; consider pre-treatment with a non-sedating antihistamine, 30 minutes prior to second vaccination. This Medicines Q&A discusses the types of lactose intolerance people may suffer from, how to determine the lactose content of medicines, and what factors healthcare…. Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate) The number 20 following the 'polyoxyethylene' part refers to the total number of oxyethylene -(CH 2 CH 2 O)- groups found in the molecule. PEGs of MW between 3350 and 6000 are frequently used as inactive ingredients in many liquid and solid formulations of medications. 19: Bencharitiwong R, Leonard S, Tsai T, Nowak-Węgrzyn A. [Comparative study on pseudoanaphylactoid reactions induced by medicinal tween 80 and injectable tween 80]. Also, if you have a known allergy to polyethylene glycol or polysorbate 80 or polysorbate 20, Dr. Bhasin recommended the patient should not receive the vaccine Second, polysorbate 80 has been used for many years as an emulsifier to make ice cream smooth and to slow melting. Advice on whether people with religious or other dietary practices can receive the AstraZeneca COVID-19 Vaccine. Contents. Lack of contact with other ingredients during the manufacturing process cannot be guaranteed. Advice on whether people with a previous allergic reaction can have the Pfizer-BioNTech COVID-19 vaccine. Lack of contact with other ingredients during the manufacturing process cannot be guaranteed. Medicaments contenant le principe actif Polysorbate 80. Read more about how we're helping below. However, AstraZeneca does not manufacture the raw materials used in its products, and the suppliers may periodically change. The AstraZeneca COVID-19 vaccine contains polysorbate 80, according to the Information for Healthcare Professionals. PEGs of MW 3350 are also the primary ingredient in commonly used oral bowel preparations for colonoscopy procedures in the United States. Polysorbate 80 is currently contained in 6821 FDA approved medications and can more commonly be found in film coated tablets, parenteral steroids, immunoglobulin replacement, and vaccines. Polysorbate 80. Objective- Tween 80 (Polysorbate 80) is a classical non-ionic surface-active detergent. It is widely used as an additive in pharmaceuticals and in the food industry. Ethoxylated surfactants are polyethers and are thus easily oxidized by atmospheric oxygen to a variety of hydroperoxides, peroxides and carbonyl compounds. Updated to reflect changes in the Green Book: "Background" section updated; "First dose of AstraZeneca COVID-19 vaccine or other medicines allergy" section updated, including addition of BSACI management advice for people who had a reaction to the first dose of vaccine; added which patients should be discussed with an allergy specialist prior to vaccination in the "other drugs" section. Although the exact mechanism of the hypersensitivity reaction is not known, it is believed to be of nonimmunogenic origin. Lack of contact with other ingredients during the manufacturing process cannot be guaranteed. Manfactured By Pharmaceutical Associates, Inc. Greenville, SC 29605 www.paipharma.com Delivers 5 mL NDC 0121-0939-05 CHILDREN'S ACTAMINOPHEN ORAL … Immediate-type hypersensitivity to all of the polysorbates can be skin tested for using the same dilutions. The manufacturer states that the vaccine does not contain gelatin. However, AstraZeneca does not manufacture the raw materials used in its products, and the suppliers may periodically change. Patients with an allergy to latex can be directed to the Anaphylaxis Campaign website for information. Inhibited ethylene glycol, antifreeze. In vitro assessment of the allergenicity of novel MF59 … Physical stability was evaluated by visual inspection to ensure homogeneity and it was packed in 1 mL syringes stored at 2–8°C for 48 hours protected from light. Awards and Scholarships; Dr. Richard L. Hall Distinguished Service Award; Dr. Richard L. Hall Scholarship in Flavor Science; Emerging Leader Award; FEMA College Scholarship Program ; FEMA Excellence in Flavor Science Award; President's … The manufacturer states that the vaccine does not contain eggs. Polysorbate 80 allergy The AstraZeneca COVID-19 vaccine contains polysorbate 80, according to the Information for Healthcare Professionals. The binding of these antibodies increased as the molecular weight of the polyethylene glycol increased, suggesting that higher molecular weight PEG products like PEG 3350 might be more likely to cause a reaction. We hypothesize that polysorbate 80 inhibits uptake transporters in the intestine, which absorb valacyclovir and chenodeoxycholic acid in the gut via the peptide transporter 1 (PepT1) and apical sodium-bile acid transporter (ASBT), respectively. one of the vaccines (such as a known allergy to PEG or Polysorbate 80), it may be possible to have another vaccine which does not contain the ingredient, subject to availability and medical advice. Added "Flowchart for managing patients who have allergic reactions to the first dose of COVID-19 vaccine" to "First dose of AstraZeneca COVID-19 vaccine or other medicines allergy" section; added a new section "Summary of allergy considerations", including a summary table. However, even if the components of an injection do not contain latex, or latex is not used as a raw material during manufacturing, most manufacturers of injectable products advise they cannot guarantee minute amounts of latex are not contained in raw materials obtained from their suppliers or the product has not come into contact with latex during the manufacturing process. The manufacturer states that the vaccine does not contain any peanut or tree nut derivatives. However, it also states that the following individuals should be discussed with an allergy specialist, prior to vaccination: Public Health England’s Immunisation Against Infectious Disease (the Green book) states that individuals with previous allergy to in an identified drug, including anaphylaxis, can receive the AstraZeneca COVID-19 vaccine. Persons with a reaction to a vaccine or injectable therapy that contains multiple components, one of which is PEG, another mRNA vaccine component or polysorbate, but in whom it is unknown which component elicited the immediate allergic reaction … The excipients listed in the manufacturer’s information are as follows: The AstraZeneca COVID-19 vaccine contains polysorbate 80, according to the Information for Healthcare Professionals. It had polysorbate 80 in it, so I could be confident she did not have a polysorbate allergy. Information for Healthcare Professionals; Public Health England’s Immunisation Against Infectious Disease (the Green Book), Public Health England’s COVID-19 Vaccination Programme Information for Healthcare Professionals, Managing anaphylaxis in the COVID-19 vaccination setting, SPS support and the COVID-19 Vaccination Programme, Answering your questions and getting in touch, Pfizer-BioNTech Vaccine: Answers to Questions. Individuals with a prior history of systemic allergic reaction (including immediate-onset anaphylaxis) to a previous dose or any component of the AstraZeneca vaccine should not receive it. 2917 POLYSORBATE 80. search. If the reaction required medical attention, advice from an allergy specialist should be sought prior to second vaccination. High molecular weight polyethylene glycols and polysorbates are common ingredients in a wide variety of medications, household products and industrial products which may provide a vehicle for sensitizing susceptible individuals. The vaccine can be considered not to contain latex and poses the same minimal risk as other injectable medicines presented in vials with a halobutyl rubber stopper. After two cases of life-threatening immediate hypersensitivity to macrogols were encountered in their clinic, Stone, et al sought to further understand the mechanism and scope of immediate hypersensitivity to PEGs in the United States. In vaccines, polysorbate 80 keeps all the ingredients evenly distributed. She was looking forward to participating in the research very much and this allowed her to participate. Bekahd on December 13, 2020 at 2:58 am . Published online: December 14, 2018 Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions. Prorhinel rhume, solution nasale Principes actifs les plus consultés. Allergists and consumers should be aware that sensitization leading to an immediate hypersensitivity type allergy to polyether containing compounds such as polyethylene glycols and polysorbates can occur, and that such reactions may currently be under-recognized. According to the CDC, polysorbate 80 is an excipient commonly found in vaccines for influenza, Hepatitis B, HPV, and meningococcus (here). On the other hand, the amount of polysorbate 80 in each dose of the HPV vaccine — 50 micrograms* — is very small. Polysorbate 80 is currently contained in 6821 FDA approved medications and can more commonly be found in film coated tablets, parenteral steroids, immunoglobulin replacement, and vaccines. when receiving other vaccines and therefore the AstraZeneca COVID-19 vaccine is recommended as a suitable alternative. By continuing to browse this site, you are agreeing to our use of cookies. The manufacturer states that this vaccine does not contain any preservatives, thiomersal or any mercury derived product. Polysorbate 80 (also known as polyoxyethylene-20-sorbitan mono-oleate, Tween 80 and E-433) is an ethoxylated hydrophilic non-ionic synthetic compound derived from ethylene oxide, sorbitol and oleic acid. If the reaction involved swelling or rash local to injection site only, the individual can have the second dose using the same vaccine in any vaccination setting; observe for 30 minutes. Review our cookies information for more details. Dates: Modify . Our view is that the risks associated with previous latex allergy are low. 2012 Jul;37(13):1890-3. However, polysorbate 80 is widely used in medicines and foods, and is present in many medicines including monoclonal antibody preparations. Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions. Changes made to clarify advice in relation to allergies and excipients, Changes made to clarify advice in relation to other allergy considerations, including addition of advice regarding latex, Changes made to include page as part of a series covering similar topics. The degree to which PEG hypersensitivity might be a problem in the United States and the mechanism for PEG and polysorbate reactions are therefore not well understood. This is about a quarter of a teaspoon of sugar. Ann Allergy Asthma Immunol. 2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-{2-[(9E)-octadec-9-enoyloxy]ethyl}hexofuranoside. 34 Coors E, et al. In an article published in The Journal of Allergy and Clinical Immunology: In Practice, the authors first obtained detailed clinical case descriptions from two patients whose history suggested an immediate reaction to PEG 3350-containing colonoscopy preparations, laxatives, or injected corticosteroids. It remains to be determined the degree to which sensitized patients can react to medications which contain only tiny amounts of PEGs or polysorbates, compared to the much larger amounts contained in certain injectable drugs, oral colonoscopy preparations, and laxatives. The Information for Healthcare Professionals does not indicate that any “sulfa” medicines are present in the AstraZeneca COVID 19 vaccine. Polysorbates include oleic acid (Polysorbate-80), lauric acid (Polysorbate-20), and stearic acid (Polysorbate-60). Find patient medical information for polysorbate 80 on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. 1 Structures Expand this section. Lack of contact with other ingredients during the manufacturing process cannot be guaranteed. About. Recently, PEGs of this MW range have been receiving attention as a cause of severe immediate allergic reactions to bowel preparations used for colonoscopies, and as a cause of reactions to chemotherapy drugs which have been conjugated to PEGs. It is also used as an excipient in some European and Canadian influenza vaccines. Although not for use by women, cabazitaxel can cause birth defects in a baby if the father is using this medicine. depot steroid injection, laxative). The table below is a pictorial summary of the management of patients with a history of allergy, reproduced with kind permission from authors of Public Health England’s Immunisation Against Infectious Disease (the Green book). Reply. I’m independently researching the ingredients in the new Covid19 vaccine and was happy to come across this article from 2019. This is not surprising, Shimabukuro says, as PEG allergies are rare and anyone who has one may have avoided the shot. Can you really be allergic to an “inactive” ingredient? We're supporting healthcare professionals with the COVID-19 Vaccination Programme in England. Although some experts have suggested that an allergy to an ingredient in the vaccines – polyethelyene glycol or polysorbate – could be behind some of the cases of anaphylaxis, none of the 66 had a known allergy to either substance. Polysorbate 80 allergic patients should discuss their allergy with an allergist/ immunologist before receiving the Pfizer/BioNTech or Moderna COVID-19 vaccine. Finally, they evaluated the scope to which polyethylene glycol 3350 might be associated with anaphylaxis in the United States, by reviewing publicly available FDA Adverse Event Reporting System (FAERS) data and identified medications which contained either  PEG 3350 or  polysorbate 80 in the publicly available NIH Daily Med database. Whilst the AstraZeneca vaccine does not contain PEG, it contains a compound called polysorbate 80 (see AstraZeneca information for healthcare professionals); some people with PEG allergy may also be allergic to polysorbate 80. The Public Health England’s Immunisation Against Infectious Disease (the Green book) highlights that thiomersal is a mercury based compound used as a preservative in the manufacture of some vaccines for many years and has been associated with some safety concerns. If the patient had systemic symptoms (including anaphylaxis), advice from an allergy specialist should be sought prior to second vaccination. PEG is not present in the AstraZeneca COVID-19 vaccine, according to the Information for Healthcare Professionals; however, it does contain polysorbate 80. However, the AstraZeneca COVID-19 vaccine can be used as an alternative (if not otherwise contraindicated), particularly if they previously tolerated an injected influenza vaccine. A typical serving of ice cream (1/2 cup) may contain about 170,000 micrograms* of polysorbate 80. Patients with systemic allergic symptoms after the first dose of the Pfizer-BioNTech vaccine may be considered for a second dose using the AstraZeneca vaccine, and should be observed for 30 minutes following vaccination. According to good manufacturing practices, the process was carried out in a horizontal laminar flow hood, except for polysorbate 80. ANAPHYLAXIS SYMPTOMS, DIAGNOSIS, TREATMENT & MANAGEMENT », American Academy of Allergy Asthma & Immunology. aspirin, ibuprofen) or mastocytosis can proceed with vaccination as normal, according to local guidelines. Those with a history of immediate onset-anaphylaxis to multiple classes of drugs with the trigger unidentified (this may indicate PEG allergy). a severe allergic reaction to any medication. Persons with a known (diagnosed) allergy to PEG, another mRNA vaccine component, or polysorbate, have a contraindication to vaccination. This Medicines Q&A provides a summary of the currently available HRT preparations that contain lactose and suggests options for lactose-free alternatives. About; Awards and Scholarships. More... Molecular Weight: 604.8 g/mol. L'utilisation du polysorbate 80 est déjà autorisée au Canada à titre d'agent émulsifiant dans plusieurs aliments normalisés et non normalisés. Compared with its use in foods, there is very little polysorbate 80 in vaccines. High molecular weight polyethylene glycols and polysorbates are common ingredients in a wide variety of medications, household products and industrial products which may provide a vehicle for … anaphylactic) allergy to latex, would categorise the AstraZeneca vaccine as not containing latex.Â, Regional Medicines Optimisation Committees, Advising individuals with allergies on their suitability for AstraZeneca COVID-19 Vaccine, AstraZeneca Vaccine: Answers to Questions, Suitability for COVID-19 vaccination based on prior allergy or current dietary practices, Advising individuals with allergies on their suitability for Pfizer-BioNTech COVID-19 Vaccine, Advising individuals with religious or other dietary practices and beliefs on their suitability for the Pfizer-BioNTech COVID-19 Vaccine, Advising individuals with religious or other dietary practices and beliefs on their suitability for the AstraZeneca COVID-19 Vaccine, Public Health England’s Immunisation Against Infectious Disease (the Green book). Chinese. The manufacturer states that the vaccine does not contain any gluten. Public Health England’s Immunisation Against Infectious Disease (the Green Book) advises that the AstraZeneca vaccine may be used as an alternative in people with a PEG allergy. The vaccine should be administered in a setting with full resuscitation facilities (e.g. Extended Navigation. back Awards and Scholarships. Excipients most commonly implicated are flavourings such as spearmint,…, The first stop for professional medicines advice, on managing vaccine choice in patients with severe (i.e. It is used as surfactant, stabiliser and emulsifier in the composition of cosmetics, industrial detergents and in a wide variety of topical, oral and parenteral drugs. Polysorbate 80 (glycol) Polyoxyethylene 20 sorbitan monooleate. 2005 Dec;95(6):593-9.doi: 10.1016/S1081-1206(10)61024-1. … The number following the 'polysorbate' part is related to the type of fatty acid associated with the polyoxyethylene sorbitan part of the molecule. Allergist / Immunologists: Specialized Skills. Prior allergy and religious or other dietary requirements could occasionally affect suitability for vaccination, and patients will often have questions. Call 1-800-845-8210. However, AstraZeneca does not manufacture the raw materials used in its products, and the suppliers may periodically change. The Information for Healthcare Professionals states that a hypersensitivity to any of the excipients is a contraindication to the vaccine use. Polyethylene glycol (PEG) allergy Public Health England’s Immunisation Against Infectious Disease (the Green book) states that: Below is a summary of knowledge about suitability for vaccination based on previous allergy status. Here in this study an attempt was made to find out whether the tween 80 used as an excipient in an anti cancer drug, Methotrexate affected its therapuetic efficiency or not. They then determined these patients’ clinical reactivity to macrogols, including polyethylene glycols and polysorbate-containing products, using a combination of controlled skin prick, intradermal and challenge tests. The Oxford-AstraZeneca vaccine does not contain PEG 2000 so remains an alternative for people with a history of allergy to this ingredient.2 However, there is some cross-reactivity between PEG and polysorbate 80, an ingredient in the Oxford-AstraZeneca vaccine, so evaluation by an allergy specialist may be advisable before vaccination in anyone with a suspected PEG allergy history.14 … Find patient medical information for polysorbate 80-glycerin ophthalmic (eye) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. … Currently, there is only limited awareness of the role of PEGs in reactions to medications where they are present as an ingredient. Advice on whether people with a previous allergic reaction can have the AstraZeneca COVID-19 vaccine. an allergy to any medicine that contains polysorbate 80.
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